Error Code 5461
This error code means that you are attempting to use a barcode number on a brand name item. Amazon has a Brand Registry; Brands register their own barcodes through this program. The barcode you are attempting to use does not match that Brand.
For example, if you were listing a Nike shoe but trying to use your own barcode then it will fail with this error code - because your barcode is different from Nike's own Amazon Brand registered barcode numbers.
Solution:
Do not input the Brand's name (so Nike in the example above) in the brand field, but instead input your DBA or Amazon company name in the Brand field and then input the Brand's name (example: Nike) in the item description.